|
KMID : 1004820100110040225
|
|
Journal of Biomedical Research
2010 Volume.11 No. 4 p.225 ~ p.234
|
|
|
L-teanine Inhibits Cancer Cell Growth through Activation of ERK
|
|
Hong Jin-Tae
Ban Jung-Ok
Kwon Hyo-Jin
Oh Ju-Hoon
Won Do-Hee
Nam Sang-Yoon
Kim Dae-Joong
Lee Beom-Jun
Yun Young-Won
Lee Ung-Soo
Han Sang-Bae
|
|
|
Abstract
|
|
|
|
Limited studies showed that L-theanine, an amino acid component of green tea, inhibit cancer cell growth. However, combination effects with other well prescribed anti-cancer drugs, and possible mechanisms are not reported. In the present study, L-theanine (0, 0.25, 0.5 and 1 mM) did not inhibit cell proliferation in most of cancer cells. However, the combination with several well prescribed anti-cancer drugs showed differential inhibitory effects. In colon cancer cells, the combination effect was seen by the combination with oxaliplatin in SW620 cells, but the combination effect was seen by 5-fluorouracil (5- FU) in HCT116 cells. The combination effects with doxorubicin in LNCap cells, and docetaxel in PC3 prostate cancer cells and MKN45 gastric cancer cells, with doxorubicin in A549 cells and Hep G2 cells were observed. Most significant combination effects were detected in the combination with doxorubicin in the LNCap prostate, A549 lung and Hep G2 liver cancer cells. We also found that sustained extracellular signal- regulated kinase 1/2 (ERK1/2) activation is involved in cancer cell growth inhibition by the combination effect of L-theanine with anti-cancer drugs. These results suggested that L-theanine has differential combination effects on the cancer cell growth inhibition with well prescribed anti-cancer drugs, and sustained activation of the mitogen-activated protein kinase (MAPK)/ERK is involved in the combination-induced growth inhibition.
|
|
|
KEYWORD
|
|
|
L-teanine, ERK, Combination therapy, Human colon cancer cells, Human prostsate cancer cells
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|